Precast concrete systems are widely used in building and bridge structures, due to their well-known advantages, namely higher quality, increased durability, and shorter construction times. In residential buildings, these benefits can be further enhanced by combining prefabrication with modularization. In this context, optimizing existing solutions is crucial to achieving even lower costs and reduced execution times. To establish this new paradigm, it is vital to develop more efficient construction systems that align with prefabricated modular construction, making it a truly competitive alternative to traditional building methods. Structural walls, in particular, present several advantages by consolidating multiple functions, such as architectural (façade), structural, thermal, and acoustic, into a single element. Current prefabricated walls on the market have untapped potential for improvement, especially in terms of multi-functionality. Herein, the results of an experimental program developed aiming at enhancing the structural and thermal performance of a prefabricated wall solution are presented. The wall’s crosssection was reduced by approximately 20%, leading to a significant decrease in material consumption, while maintaining comparable structural, acoustic and thermal performance. The experimental results validated the proposed solution, particularly in terms of its shear strength under loads applied perpendicular to the wall’s plane, which simulate scenarios such as strong wind or seismic events.